Hong Sun, Ph.D.

Assistant Professor
Ph.D., 1999, Mie University Graduate School of Medicine
Department of Cellular Biology and Anatomy
1501 Kings Highway
LSU Health Sciences Center
Shreveport, LA 71130
Phone: 318.675.4566
Fax: 318.675.5889
Email: hsun1@lsuhsc.edu
 

Major Research Interests: Dr. Sun’s research focuses on the influences of alcohol consumption and obesity on cerebrovascular structure, function and ischemic brain injury.  His research involves examining oxidative stress, apoptosis, inflammation and excitotoxicity.

Ongoing cardiovascular-related projects:

1. Light Alcohol Consumption and Ischemic Stroke.
Brief description: The goal of our proposed studies is to determine the mechanism underlying the neuroprotective effect of light alcohol consumption (LAC) in transient focal cerebral ischemia. We hypothesize that LAC protects against cerebral ischemia/reperfusion (I/R) injury by suppressing inflammation and apoptosis via lipocalin-type prostaglandin D2 synthase (L-PGDS)-dependent nuclear peroxisome proliferator-activated receptor gamma (PPARγ)-mediated manganese superoxide dismutase (MnSOD) upregulation. A blend of physiological studies with pharmacological, biochemical and genetic approaches will be utilized to determine the roles of L-PGDS, PPARγ and MnSOD in the inhibitory effect of LAC on vascular endothelial cell activation, blood-brain barrier (BBB) disruption and neuronal apoptosis following transient focal cerebral ischemia.
Names of collaborators / collaborating institutions: Dr. William Mayhan
Funding source: LSUHSC-Shreveport startup package

2.  Obesity and Ischemic Stroke
Brief description: The goal of our proposed studies is to determine the mechanism underlying the detrimental effect of obesity in transient focal cerebral ischemia. We recently found obesity worsens early BBB disruption following transient focal cerebral ischemia. In addition, protein expression of tight junction is downregulated in obesity. We will continue studying the influence of obesity on inflammation and apoptosis following ischemic stroke.
Collaborators: Dr. William Mayhan
Funding source: LSUHSC-Shreveport startup package

Planned cardiovascular-related projects:

  1. Light Alcohol Consumption and Diabetes

Methods and Available Resources:

  • We recently developed a new mouse model of transient focal cerebral ischemia. A cranial window was prepared over the left frontal, parietal and temporal cortex in mice. Transient focal cerebral Ischemia was induced by directly ligating the middle cerebral artery (MCA). There are several strengths using this new model. First, a complete obstruction of CBF to the MCA territory can be directly identified under the surgical microscope. Second, the cranial window makes the topical treatment possible, and thus avoids the systemic influence of experimentally tested agonists/antagonists and neuroprotective agents. Third, response of cerebral vasculature during either systemic or topical treatment of the drugs can be measured in real time.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=hong+sun+louisiana

http://www.ncbi.nlm.nih.gov/pubmed/?term=hong+sun+nebraska