Karen Stokes, Ph.D.
Ph.D., 2004 – Trinity College Dublin
Department of Molecular and Cellular Physiology
LSU Health Sciences Center
1501 Kings Highway
Shreveport, LA 71130
Phone: 318- 675-8420
Major Research Interests: The Inflammatory Impact of Cytomegalovirus on the Microvasculature, and its Cooperation with Other Cardiovascular Risk Factors. Inflammation is a key player in the pathogenesis of cardiovascular disease. In the case of several cardiovascular risk factors, including hypercholesterolemia, clinical signs of disease are preceded by the development of an inflammatory phenotype in the microvasculature, which may promote a low-grade systemic inflammation rendering tissues more susceptible to injurious stimuli or other risk factors. Recent epidemiological studies have revealed that infectious agents, for example cytomegalovirus (CMInflammatory Impact of Cytomegalovirus on the MicrovasculatureV), may contribute to cardiovascular disease. CMV is a b -herpesvirus that has been identified in atherosclerotic lesions, and accelerates disease progression in hyperlipidemic animals. CMV induces an inflammatory phenotype in isolated cells. Our preliminary data suggests that CMV also induces endothelial dysfunction in arterioles in vivo, and exacerbates hypercholesterolemia-induced blood cell recruitment in postcapillary venules. Therefore our focus is to investigate the underlying mechanisms involved in the microvascular responses to CMV, and its cooperation with hypercholesterolemia in the generation of a pro-inflammatory phenotype.
Ongoing cardiovascular-related projects:
Planned cardiovascular-related projects:
Methods and Available Resources: