Matthew D. Woolard, Ph.D.
Ph.D., Biomedical Sciences, 2004, University of North Texas Health Science Center at Fort Worth
Department of Microbiology
1501 Kings Highway
LSU Health Sciences Center
Shreveport, LA 71130
Office Phone: 318-675-5763
Laboratory Phone: 318-675-4160
Office Fax: 318-675-5764
Major Research Interests: Francisella tularensis host-pathogen interaction with emphasis on immune evasion. Pathogenic bacteria and their hosts have had a two-way conversation for millions of years. This interaction has led to many measure/counter-measure responses by the host and bacteria. The host immune response has developed many mechanisms to neutralize and remove pathogen bacteria. In turn, pathogenic bacteria have developed mechanisms to alter and evade the host immune response. F. tularensis clearly manipulates the host to alter immune responses. The molecular mechanisms and consequences of host immune evasion by F. tularensis are poorly defined. My laboratory is interested in defining these molecular mechanisms and interactions of immune evasion. We are currently investigating the ability of F. tularensis to induce the production of prostaglandin E2 (PGE2) from infected macrophages. The induction of PGE2 inhibits T lymphocyte proliferation and the generation of strong pro-inflammatory Th1 T lymphocytes. These alterations in cellular immunity impact the clearance of F. tularensis from the lungs of infected mice. Experiments are in progress to identify the prokaryotic effector molecule and the eukaryotic sensor responsible for instructing the macrophage to make and secrete PGE2. We are also investigating the impact of PGE2 production on the generation of T cell responses during respiratory tularemia.
Ongoing cardiovascular-related projects:
Planned cardiovascular-related projects:
Methods and Available Resources: