Sushil Jain, Ph.D.
Professor of Pediatrics and Molecular and Cellular Physiology; Biochemistry and Molecular Biology
Member, CCDS Board of Directors
Malcolm Feist Chair in Diabetes
Ph.D., 1976, Institute of Medical Education and Research
Major Research Interests: Dr. Jain’s major research interests include nutrition, free radicals, and cellular damage in health and disease. Our interests are in oxidative stress, ketosis, insulin resistance, nutrition, and the pathophysiology of diabetes. Diabetes is associated with elevated blood levels of glucose and ketone bodies, which lead to the cellular damage and the complications associated with diabetes. To understand the biochemical mechanisms that cause insulin resistance and cellular damage in diabetes, our group is studying effects of the ketone bodies acetoacetate and β-hydroxybutyrate on the expression and regulation of pro-inflammatory cytokines, adhesion molecules, glucose transporters, and NFĸB in monocyte, endothelial cell, and adipocyte models. Specifically, we are interested in studying the role of free radicals, lipid peroxidation, and protein oxidation in the cellular dysfunction associated with diabetes. In addition, we are using cell culture, diabetic rat models, and diabetic patients to examine whether various antioxidative micronutrients, such as vitamin D, vitamin E, chromium, L-cysteine, curcumin, and compounds found in broccoli, may prevent or reduce cellular damage, vascular inflammation, and cardiovascular disease. We are also studying the role of hydrogen sulfide in insulin resistance and membrane oxidative damage in type 1 and type 2 diabetes. The incidence of glucose-6-phosphate dehydrogenase deficiency in African-Americans is nearly 10% compared with 1% in Caucasians. We are investigating whether the increased severity of complications of diabetes in African-Americans is associated with an increased vulnerability of glucose-6-phosphate dehydrogenase-deficient cells to glucose-induced oxidative damage.
Ongoing cardiovascular-related projects:
Planned cardiovascular-related projects:
Methods and Available Resources: